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Fabgennix
PTP alpha Polyclonal Antibody
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Product Details
PTPRA-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 650-700 on human Receptor-type tyrosine-protein phosphatase Alpha protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation - it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hptp alpha; LCA-related phosphatase; Leukocyte common antigen-related peptide (protein tyrosine phosphate); protein tyrosine phosphatase alpha; protein tyrosine phosphatase, receptor type, A; protein tyrosine phosphatase, receptor type, alpha polypeptide; Protein-tyrosine phosphatase alpha; PTP alpha; PTPase-alpha; PTPLCA-related phosphatase; PTPTY-28; R-PTP-alpha; Receptor-type tyrosine-protein phosphatase alpha; RPTP alpha; tyrosine phosphatase alpha
Gene Aliases: HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; Ptpalpha; PTPRA; PTPRL2; R-PTP-alpha; RPTPA; Rptpalpha; Rptra; Rptralpha
UniProt ID: (Human) P18433, (Mouse) P18052
Entrez Gene ID: (Human) 5786, (Mouse) 19262, (Rat) 25167
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
protein complex binding
protein phosphatase
protein modifying enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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