Immunogen sequence: SKSYSYSEVL PIEGPPSFRG QSVKYVYKLT IGCQRVNSPI TLLRVPLRVL VLTGLQDVRF PQDEAVAPSS PFLEEDEGGK KDS
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Retrograde golgi transport homolog 1 (RGP1) is the mammalian homolog to the yeast RGP1, a protein that forms a tight complex with RIC1. This complex binds Ypt6p and stimulates guanine nucleotide exchange. RGP1 is localized to the Golgi and is thought to be a potential Golgi recycling factor. Rgp1 yeast mutants exhibit defects in retrograde trafficking similar to those seen in yeast with mutations in other retrograde Golgi transport proteins. It is expected that RGP1 plays a similar role in mammalian cells to that seen in yeast.
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Protein Aliases: KIAA0258; RAB6A-GEF complex partner protein 2; Retrograde Golgi transport protein RGP1 homolog; RGP1 (HGNC:21965); RGP1 retrograde golgi transport homolog
Gene Aliases: KIAA0258; RGP1
UniProt ID: (Human) Q92546
Entrez Gene ID: (Human) 9827