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Proteintech
RGS4 Polyclonal Antibody
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Product Details
14530-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RGS4 Fusion Protein Ag6029 (1-205 aa encoded by BC051869)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MCKGLAGLP ASCLRSAKDM KHRLGFLLQK SDSCEHNSSH NKKDKVVICQ RVSQEEVKKW AESLENLISH ECGLAAFKAF LKSEYSEENI DFWISCEEYK KIKSPSKLSP KAKKIYNEFI SVQATKEVNL DSCTREETSR NMLEPTITCF DEAQKKIFNL MEKDSYRRFL KSRFYLDLVN PSSCGAEKQK GAKSSADCAS LVPQCA (1-205 aa encoded by B C051869)
Target Information
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; MGC2124; MGC60244; Regulator of G-protein signaling 4; RGP4; RGS4; RP11-430G6.1; schizophrenia disorder 9; unnamed protein product
Gene Aliases: AA004315; AA597169; ESTM48; ESTM50; RGP4; RGS4; SCZD9
UniProt ID: (Human) P49798, (Mouse) O08899, (Rat) P49799
Entrez Gene ID: (Human) 5999, (Mouse) 19736, (Rat) 29480
response to amphetamine
G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of signal transduction
positive regulation of heart rate
response to cocaine
response to ethanol
negative regulation of G-protein coupled receptor protein signaling pathway
regulation of calcium ion transport
negative regulation of dopamine receptor signaling pathway
negative regulation of cell growth involved in cardiac muscle cell development
regulation of actin filament organization
negative regulation of glycine import across plasma membrane
regulation of potassium ion transmembrane transport
negative regulation of potassium ion transmembrane transport
dorsal root ganglion development
positive regulation of excitatory postsynaptic potential
termination of G-protein coupled receptor signaling pathway
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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