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Invitrogen
RIP3 Polyclonal Antibody
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Product Details
PA5-85688
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human RIP3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.56 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Positive Control: THP-1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homocysteine respondent protein HCYP2; receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3
Gene Aliases: Hcyp2; RIP3; RIPK3
UniProt ID: (Human) Q9Y572, (Rat) Q9Z2P5
Entrez Gene ID: (Human) 11035, (Rat) 246240
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
cellular protein modification process
signal transduction
I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatase activity
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
NIK/NF-kappaB signaling
T cell homeostasis
regulation of activated T cell proliferation
protein autophosphorylation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
protein heterooligomerization
positive regulation of ligase activity
positive regulation of oxidoreductase activity
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
positive regulation of protein deacetylation
apoptotic signaling pathway
amyloid fibril formation
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
protein phosphorylation
signal transduction by protein phosphorylation
positive regulation of transferase activity
regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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