Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: TDLDLDTEF EILLPRRRGL GLCATALVSY LIRLHNEIVY AVEKLSKENN SYSVDAAEVT ELHVISYEVE RDLTPLILSN CQYQVEEGRE TVQEFDLEKI QRQIVSRFLQ GKPRLSLKGI PTLVYRHDWN YEHLFMDIKN KMAQDSLPSS VISAISGQLQ SYSDACEVLS VVEVTLGFLS TAGGDPNMQL NVYTQDILQM GDQTIHVLKA LNRCQLKHTI ALWQFLSAHK SEQLLRLHKE PFGEISSRYK ADLSPENAKL LSTFLNQTGL DAFLLELHEM IILKLKNPQT QTEERFRPQW SLRDTLVSYM QTKESEILPE MASQFPEEIL LASCVSVWKT AAVLKWNREM R (4858-5207 aa encoded by BC032220)
RNF213 is an E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALK lymphoma oligomerization partner on chromosome 17; E3 ubiquitin-lipopolysaccharide ligase RNF213; E3 ubiquitin-protein ligase RNF213; Mysterin; RING finger protein 213
Gene Aliases: ALO17; C17orf27; KIAA1554; KIAA1618; MYMY2; MYSTR; NET57; RNF213
UniProt ID: (Human) Q63HN8
Entrez Gene ID: (Human) 57674
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