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Bioss
RNF6 Polyclonal Antibody
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FIGURE: 1 / 1
RNF6 Antibody (BS-9172R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat testis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with RNF6 Polyclonal Antibody, Unconjugated (bs-9172R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB ... View More
Product Details
BS-9172R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RNF6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686P0776; E3 ubiquitin-protein ligase RNF6; ring finger protein (C3H2C3 type) 6; RING finger protein 6; RING-H2 protein RNF-6; RLIM-like protein
Gene Aliases: 1200013I08Rik; 5730419H05Rik; AA537053; RNF6; SPG2
UniProt ID: (Human) Q9Y252, (Mouse) Q9DBU5
Entrez Gene ID: (Human) 6049, (Rat) 304271, (Mouse) 74132
DNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
androgen receptor binding
ubiquitin protein ligase activity
molecular_function
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
negative regulation of axon extension
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K27-linked ubiquitination
positive regulation of transcription, DNA-templated
regulation of androgen receptor signaling pathway
protein K48-linked ubiquitination
protein K6-linked ubiquitination
biological_process
protein ubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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