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Invitrogen

ROC1 Polyclonal Antibody

Advanced Verification

IP-mass spectrometry

6 Published Figures
5 References
View all (15) ROC1 antibodies
Datasheet
Protocols
Questions & Answers
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

34-2500

Applications Tested Dilution Publications

Western Blot (WB)

 Assay-dependent View 5 publications 5 publications

Immunoprecipitation (IP)

 Assay-dependent -
Product Specifications

Species Reactivity

 Human, Mouse

Published species

 Human, Virus

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

specific to Human ROC1C

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 0.25 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.4

Contains

 0.1% sodium azide

Storage conditions

 -20°C

RRID

AB_2533162

Target Information

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin-protein transferase RBX1; E3 ubiquitin-protein transferase RBX1, N-terminally processed; Protein ZYP; Rbx1; Regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; ZYP protein

Gene Aliases: 1500002P15Rik; AA517855; BA554C12.1; RBX1; RNF75; ROC1

UniProt ID: (Human) P62877, (Mouse) P62878

Entrez Gene ID: (Human) 9978, (Mouse) 56438

Molecular Function: ubiquitin-protein ligase protein modifying enzyme

Function(s)
MAPK cascade protein polyubiquitination nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion protein monoubiquitination viral process Wnt signaling pathway protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein neddylation regulation of transcription from RNA polymerase II promoter in response to hypoxia global genome nucleotide-excision repair negative regulation of canonical Wnt signaling pathway DNA repair ubiquitin-dependent protein catabolic process cellular response to DNA damage stimulus protein catabolic process
Process(es)
ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity NEDD8 transferase activity ubiquitin protein ligase binding protein complex binding ubiquitin-ubiquitin ligase activity ubiquitin protein ligase activity cullin family protein binding eukaryotic initiation factor 4E binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
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