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Proteintech
RON/MST1R Polyclonal Antibody
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Product Details
11053-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RON, MST1R Fusion Protein Ag1537 (1038-1332 aa encoded by BQ936677 NM_002447)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ASFSDSEDE SCVPLLRKES IQLRDLDSAL LAEVKDVLIP HERVVTHSDR VIGKGHFGVV YHGEYIDQAQ NRIQCAIKSL SRITEMQQVE AFLREGLLMR GLNHPNVLAL IGIMLPPEGL PHVLLPYMCH GDLLQFIRSP QRNPTVKDLI SFGLQVARGM EYLAEQKFVH RDLAARNCML DESFTVKVAD FGLARDILDR EYYSVQQHRH ARLPVKWMAL ESLQTYRFTT KSDVWSFGVL LWELLTRGAP PYRHIDPFDL THFLAQGRRL PQPEYCPDSL YQVMQQCWEA DPAVRP (1038-1332 aa encoded by BQ936677 NM_002447)
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-met-related tyrosine kinase; CD136; CDw136; friend virus susceptibility 2; Macrophage-stimulating protein receptor; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; protein tyrosine kinase 8; Protein-tyrosine kinase 8; PTK8 protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related; RON variant E2E3; S13 avian erythroblastosis oncogene homolog; S13 erythroblastosis oncogene homolog; Stem cell-derived tyrosine kinase; unnamed protein product
Gene Aliases: CD136; CDw136; Fv-2; Fv2; MST1R; NPCA3; p185-Ron; PTK8; RON; SEA; STK
UniProt ID: (Human) Q04912, (Mouse) Q62190
Entrez Gene ID: (Human) 4486, (Rat) 300999, (Mouse) 19882
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
macrophage colony-stimulating factor receptor activity
protein binding
ATP binding
kinase activity
transferase activity
enzyme binding
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
immune system process
phagocytosis
defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
single fertilization
nervous system development
positive regulation of cell proliferation
response to virus
cell migration
macrophage colony-stimulating factor signaling pathway
positive regulation of MAP kinase activity
innate immune response
positive regulation of protein kinase B signaling
multicellular organism development
peptidyl-tyrosine phosphorylation
protein phosphorylation
viral process
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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