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Product Details
15799-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
RPL29 Fusion Protein Ag8510 (1-159 aa encoded by BC008926) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.14 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MAKSKNHTT HNQSRKWHRN GIKKPRSQRY ESLKGVDPKF LRNMRFAKKH NKKGLKKMQA NNAKAMSARA EAIKALVKPK EVKPKIPKGV SRKLDRLAYI AHPKLGKRAR ARIAKGLRLC RPKAKAKAKA KDQTKAQAAA PASVPAQAPK RTQAPTKASE (1-159 aa encoded by BC008926)
Target Information
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 60S ribosomal protein L29; Cell surface heparin-binding protein HIP; heparin/heparan sulfate-binding protein; heparin/heparan sulfate-interacting protein; HP/HS-interacting protein; Large ribosomal subunit protein eL29; P23; ribosomal protein YL43 homologue
Gene Aliases: HIP; HUMRPL29; L29; RPL29; RPL29_3_370; RPL29P10; Rpl43
UniProt ID: (Human) P47914, (Rat) P25886, (Mouse) P47915
Entrez Gene ID: (Human) 6159, (Rat) 29283, (Mouse) 19944
Molecular Function:
ribosomal protein
translational protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
cytoplasmic translation
rRNA processing
translation
translational initiation
SRP-dependent cotranslational protein targeting to membrane
embryo implantation
viral transcription
cell-cell adhesion
cell proliferation
cell-substrate adhesion
multicellular organism growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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