A suggested positive control is rat brain tissue lysate.
PA5-21058 can be used with blocking peptide PEP-1172.
Shisa proteins are a recently-identified family of modulators of both FGF and Wnt signaling that block both maturation and transport to the cell surface of their respective receptors. SHISA9, also known as CKAMP44a, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. It is thought to modulate short-term plasticity at specific excitatory synapses.
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Protein Aliases: CKAMP44; cystine-knot AMPAR modulating protein; Cystine-knot AMPAR modulating protein of 44 kDa; Protein shisa-9; shisa family member 9; shisa homolog 9; shisa homolog 9-like
Gene Aliases: 2700045P11Rik; CKAMP44; SHISA9