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          • Primary Antibodies ›
          • STAT5 alpha/beta Antibodies

          Invitrogen

          STAT5 alpha/beta Polyclonal Antibody

          Advanced Verification
          1 Published Figure
          1 Reference
          View all (22) STAT5 alpha/beta antibodies

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          Cite STAT5 alpha/beta Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (6)
          • Published Figures (1)
          • Advanced Verification (2)
          STAT5 alpha/beta Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          STAT5 alpha/beta Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 9

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          STAT5 alpha/beta Antibody (44-368G) in ICC/IF

          Immunofluorescence analysis of Signal transducer and activator of transcription 5B was performed using 70% confluent log phase U-87 MG cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with STAT5 alpha/beta Polyclonal Antibody (Product # 44-368G) at 1:10... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          STAT5 alpha/beta Antibody in Immunocytochemistry (ICC/IF)
          STAT5 alpha/beta Antibody in Immunocytochemistry (ICC/IF)
          STAT5 alpha/beta Antibody in Western Blot (WB)
          STAT5 alpha/beta Antibody in Western Blot (WB)
          STAT5 alpha/beta Antibody in Western Blot (WB)
          STAT5 alpha/beta Antibody in Western Blot (WB)
          STAT5 alpha/beta Antibody in Western Blot (WB)
          STAT5 alpha/beta Antibody
          STAT5 alpha/beta Antibody

          Product Details

          44-368G

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          The antiserum was produced against a chemically synthesized peptide derived from an internal region of human STAT 5. The sequence is conserved in human, mouse and rat.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Purification

          Antigen affinity chromatography

          Storage buffer

          Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533641

          Target Information

          The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: epididymis secretory sperm binding protein; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B; unnamed protein product

          View more View less

          Gene Aliases: AA959963; GHISID2; MGF; Mpf; STAT5; STAT5A; STAT5B

          View more View less

          UniProt ID: (Human) P42229, (Human) P51692, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) P42232

          View more View less

          Entrez Gene ID: (Human) 6776, (Human) 6777, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851

          View more View less

          Function(s)
          RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding phosphate ion binding sequence-specific DNA binding DNA-binding transcription factor binding chromatin binding glucocorticoid receptor binding identical protein binding protein homodimerization activity protein dimerization activity RNA polymerase II core promoter sequence-specific DNA binding double-stranded DNA binding signal transducer activity protein phosphatase binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription factor
          Process(es)
          mitotic cell cycle luteinization natural killer cell differentiation positive regulation of endothelial cell proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade female pregnancy lactation cell proliferation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage lymphocyte differentiation regulation of cell adhesion B cell differentiation erythrocyte differentiation eosinophil differentiation regulation of epithelial cell differentiation mammary gland development positive regulation of interleukin-2 production positive regulation of natural killer cell differentiation mast cell apoptotic process negative regulation of mast cell apoptotic process myeloid cell apoptotic process negative regulation of myeloid cell apoptotic process T cell differentiation in thymus interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway reelin-mediated signaling pathway interleukin-5-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway interleukin-3-mediated signaling pathway thrombopoietin-mediated signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell proliferation natural killer cell mediated cytotoxicity gamma-delta T cell differentiation T cell homeostasis response to peptide hormone positive regulation of blood vessel endothelial cell migration positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development positive regulation of inflammatory response activated T cell proliferation mast cell differentiation positive regulation of mast cell differentiation JAK-STAT cascade involved in growth hormone signaling pathway prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development mast cell proliferation positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus regulation of hemopoiesis negative regulation of T-helper 17 cell lineage commitment natural killer cell proliferation sex differentiation response to estradiol positive regulation of natural killer cell proliferation cellular response to hormone stimulus erythropoietin-mediated signaling pathway progesterone metabolic process positive regulation of erythrocyte differentiation response to interleukin-2 response to interleukin-4 response to interleukin-15 cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus mast cell migration allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process peptidyl-tyrosine phosphorylation response to nutrient levels prolactin signaling pathway negative regulation of apoptotic process positive regulation of interleukin-2 biosynthetic process response to ethanol creatinine metabolic process multicellular organismal reproductive process mammary gland involution response to hypoxia liver development acute-phase response response to lipopolysaccharide positive regulation of smooth muscle cell proliferation positive regulation of cellular component movement
          It has to be done as per old AB suggested Products section.

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