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Agrisera
SUN1,2 (nuclear envelope protein) Polyclonal Antibody
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FIGURE: 1 / 2
SUN1,2 (nuclear envelope protein) Antibody (AS15-2856) in ICC/IF
Immunofluorescent localization of SUN 1,2 on suspension culture of Arabidopsis thaliana, using anti-SUN 1,2 antibodies (AS15 2,856) and anti-rabbit Ig G Dy Light® 488 conjugated secondary antibodies (AS10 1,165). DAPI staining of nuclei is pseudocolored red. Material: Suspension cultures of Arabidopsis thaliana, ecotype Landsberg erecta cv. MM 1 Fixation: Packed cell volume to fixer ratio: 250 µL: 5 mL Fixe... View More
Product Details
AS15-2856
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Plant
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
KLH-conjugated synthetic peptide derived from SUN1,2 sequences of Arabidopsis thaliana SUN1 and SUN2.
Conjugate
Form
Lyophilized
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Specific Species Reactivity: Arabidopsis thaliana
Target Information
SUN1 and SUN2 encode conserved Sad1/UNC84 (SUN) family proteins that reside predominantly in the inner nuclear membrane, where their N-terminal regions face the nucleoplasm and their C-terminal SUN domains extend into the perinuclear space. Both proteins are type II membrane proteins with a single transmembrane helix and a long luminal/coiled-coil-rich region that promotes SUN oligomerization (notably SUN2 forms homotrimers), positioning the SUN domain to bind the luminal KASH motifs of outer nuclear membrane nesprins and thereby assemble LINC complexes spanning the nuclear envelope. Through these SUN-KASH interactions, SUN1/2 mechanically couple the nuclear lamina/chromatin environment to cytoskeletal networks (actin, intermediate filaments, and microtubules via distinct nesprin partners), supporting nuclear positioning, cell polarity and migration, and cellular mechanical stiffness; disruption of SUN-KASH coupling displaces nesprins from the nuclear envelope and impairs intracellular force transmission. In specialized contexts, SUN1 is also required for meiotic telomere attachment and chromosome movement at the nuclear envelope, linking LINC complex function to gametogenesis and genome dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARABIDOPSIS SAD1/UNC-84 DOMAIN PROTEIN 1; ARABIDOPSIS SAD1/UNC-84 DOMAIN PROTEIN 2; ATSUN1; ATSUN2; MUG13.15; MUG13_15; SAD1/UNC-84 domain protein 1; SAD1/UNC-84 domain protein 2
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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