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Invitrogen
Syntaxin 1 Polyclonal Antibody
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FIGURE: 1 / 2
Syntaxin 1 Antibody (PA5-28431) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Syntaxin 1 was performed in DIV9 rat E18 primary cortical neurons fixed in 4% paraformaldehyde at RT for 15 min. Green: Syntaxin 1 Polyclonal Antibody (Product # PA5 28431) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, a neuron cell marker. Blue: Fluoroshield with DAPI.
Product Details
PA5-28431
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide encompassing a sequence within the Intracellular domain of human Syntaxin 1a. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
9.3 mg/mL
Amount
930 µg
Purification
Protein A
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, Molt-4.
Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neuron-specific antigen HPC-1; P35A; STX1A; STX1B; STX1B1; STX1B2; STXA1; Synaptotagmin-associated 35 kDa protein; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1A; Syntaxin-1B1; Syntaxin-1B2; unnamed protein product
Gene Aliases: HPC-1; P35-1; Sap; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623, (Rat) P32851
Entrez Gene ID: (Human) 6804, (Rat) 116470
SNARE binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein binding, bridging
myosin head/neck binding
identical protein binding
ATP-dependent protein binding
ion channel binding
macromolecular complex binding
calcium-dependent protein binding
glycoprotein binding
protein domain specific binding
protein heterodimerization activity
protein N-terminus binding
SNARE protein
positive regulation of neurotransmitter secretion
neurotransmitter transport
intracellular protein transport
exocytosis
vesicle fusion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
synaptic vesicle exocytosis
synaptic vesicle docking
vesicle-mediated transport
protein sumoylation
calcium ion regulated exocytosis
regulation of exocytosis
insulin secretion
secretion by cell
positive regulation of catecholamine secretion
SNARE complex assembly
regulated exocytosis
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
hormone secretion
vesicle docking
synaptic vesicle endocytosis
regulation of insulin secretion
protein localization to membrane
modulation of excitatory postsynaptic potential
positive regulation of excitatory postsynaptic potential
synaptic vesicle fusion to presynaptic active zone membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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