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Invitrogen
TADA3L Polyclonal Antibody
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Product Details
PA5-83596
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TADA3. Recombinant protein control fragment (Product #RP-89403).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LAKEEVSRQE LRQRVRMADN EVMDAFRKIM AARQKKRTPT KKEKDQAWKT LKERESILKL LDG
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADA3 homolog; ADA3-like protein; alteration/deficiency in activation 3; FLJ20221; FLJ21329; hADA3; STAF54; Transcriptional adapter 3; Transcriptional adapter 3-like
Gene Aliases: ADA3; hADA3; NGG1; STAF54; TADA3; TADA3L
UniProt ID: (Human) O75528
Entrez Gene ID: (Human) 10474
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
histone acetyltransferase activity
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mitotic nuclear division
positive regulation of gene expression
intracellular estrogen receptor signaling pathway
regulation of histone deacetylation
regulation of protein stability
histone H3 acetylation
positive regulation of transcription, DNA-templated
regulation of tubulin deacetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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