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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid peptide near the amino terminus of human TCF12.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||10 µg/ml|
|Western Blot (WB)||0.5-1 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is Hela cell lysate.
PA5-21039 can be used with blocking peptide PEP-1153.
TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation. Recent reports have shown that TCF12 is also a critical factor required for the development of invariant natural killer T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
class A helix-loop-helix transcription factor ME1; class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein; HEB, HTF4, HsT17266, bHLHb20; helix-loop-helix transcription factor 4; salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBP-alpha; TCF-12; transcription factor 12; transcription factor HTF-4
A130037E08Rik; ALF1; BHLHB20; CRS3; HEB; HEBAlt; HsT17266; HTF-4; HTF4; ME1; Meb; REB; SCBPA; TCF-12; TCF12