Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Additional Information: This antibody is expected to recognize isoform a (NP_036586.2) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2
Gene Aliases: KIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5
Entrez Gene ID: (Human) 26230
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