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FIGURE: 1 / 5
Positive Samples: SW620, HeLa, MCF7, U-87MG, Mouse skeletal muscle, Mouse lung; Cellular Location: Cytoplasm, cytoskeleton
Immunogen sequence: MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD
TPM2 (tropomyosin 2) is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers. TPM2 binds to actin filaments in muscle and non-muscle cells. Plays a central role in association with the troponin complex in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Mutations in this gene can cause nemaline myopathy 4, arthrogryposis dital 1A/2B, and cap myopathy 2.
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Protein Aliases: Beta-tropomyosin; epididymis secretory protein Li 273; nemaline myopathy type 4; RP11-112J3.4; tropomyosin; Tropomyosin beta chain; Tropomyosin-2
Gene Aliases: AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB; Tpm-2; TPM2; Trop-2
UniProt ID: (Human) P07951, (Rat) P58775, (Mouse) P58774
Entrez Gene ID: (Human) 7169, (Rat) 500450, (Mouse) 22004
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