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Proteintech
TRPC4 Polyclonal Antibody
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Product Details
21349-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRPC4 Fusion Protein Ag15698 (746-977 aa encoded by BC104725)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FRFEVLGLL RGSKLSTIQS ANASKESSNS ADSDEKSDSE GNSKDKKKNF SLFDLTTLIH PRSAAIASER HNISNGSALV VQEPPREKQR KVNFVTDIKN FGLFHRRSKQ NAAEQNANQI FSVSEEVARQ QAAGPLERNI QLESRGLASR GDLSIPGLSE QCVLVDHRER NTDTLGLQVG KRVCPFKSEK VVVEDTVPII PKEKHAKEED SSIDYDLNLP DTVTHEDYVT TRL (746-977 aa encoded by BC104725)
Target Information
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. TRPC4 forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4. The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7). Diseases associated with TRPC4 include Photosensitive Epilepsy.CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels. CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha TRPC4; beta TRPC4; beta-2 TRPC4; capacitative calcium entry channel 1; Capacitative calcium entry channel Trp4; CCE1; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; putative capacitative calcium entry channel; Receptor-activated cation channel TRP4; Short transient receptor potential channel 4; transient receptor potential cation channel, subfamily C, member 4; transient receptor potential channel 4; transient receptor potential protein 4; transient receptor protein 4; Trp-related protein 4; TRPC 4; TrpC4; Trpc4_v2
Gene Aliases: CCE1; HTRP-4; HTRP4; STRPC4; TRP4; TRPC4; Trrp4
UniProt ID: (Human) Q9UBN4, (Mouse) Q9QUQ5
Entrez Gene ID: (Human) 7223, (Rat) 84494, (Mouse) 22066
calcium ion transport
manganese ion transport
gamma-aminobutyric acid secretion
oligodendrocyte differentiation
regulation of cytosolic calcium ion concentration
regulation of calcium ion transport
calcium ion import
calcium ion transmembrane transport
transport
ion transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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