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Proteintech
UCP2 Polyclonal Antibody
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Product Details
11081-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UCP2 Fusion Protein Ag1551 (1-309 aa encoded by BC011737)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detect a band around 28-33 kDa corresponding to UCP2 protein in mouse liver, skeletal muscle and pancreas. Some upper and lower bands also were observed due to the dimer formation and degradation of the UCP2 protein. This antibody was raised against the full-length UCP2 protein and may cross-react with UCP3. It is notable that UCP2 is known to have a very short half-life less than 1 hour. It is strongly recommended that fresh-made lysate be used for western blot assays.
Immunogen sequence: MVGFKATDV PPTATVKFLG AGTAACIADL ITFPLDTAKV RLQIQGESQG PVRATASAQY RGVMGTILTM VRTEGPRSLY NGLVAGLQRQ MSFASVRIGL YDSVKQFYTK GSEHASIGSR LLAGSTTGAL AVAVAQPTDV VKVRFQAQAR AGGGRRYQST VNAYKTIARE EGFRGLWKGT SPNVARNAIV NCAELVTYDL IKDALLKANL MTDDLPCHFT SAFGAGFCTT VIASPVDVVK TRYMNSALGQ YSSAGHCALT MLQKEGPRAF YKGFMPSFLR LGSWNVVMFV TYEQLKRALM AACTSREAPF (1-309 aa encoded by BC011737)
Target Information
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dicarboxylate carrier SLC25A8; Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein; uncoupling protein 2 (mitochondrial, proton carrier); Uncoupling protein 2, mitochondrial
Gene Aliases: BMIQ4; SLC25A8; UCP2; UCPH
UniProt ID: (Human) P55851, (Rat) P56500, (Mouse) P70406
Entrez Gene ID: (Human) 7351, (Rat) 54315, (Mouse) 22228
protein binding
secondary active sulfate transmembrane transporter activity
hydrogen ion transmembrane transporter activity
chloride transmembrane transporter activity
oxaloacetate transmembrane transporter activity
malate transmembrane transporter activity
L-aspartate transmembrane transporter activity
antiporter activity
oxidative phosphorylation uncoupler activity
GDP binding
protein homodimerization activity
phosphate ion uniporter activity
molecular_function
transporter
secondary carrier transporter
mitochondrial fission
response to superoxide
response to hypoxia
glycolytic process
glutamine metabolic process
mitochondrial transport
response to cold
response to glucose
inorganic anion transport
C4-dicarboxylate transport
long-chain fatty acid transport
macrophage differentiation
cellular response to insulin stimulus
cellular response to hormone stimulus
cellular response to amino acid starvation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of mitochondrial membrane potential
transmembrane transport
negative regulation of insulin secretion involved in cellular response to glucose stimulus
response to fatty acid
L-aspartate transmembrane transport
cellular response to lead ion
cellular response to glucose stimulus
malate transmembrane transport
response to dexamethasone
reactive oxygen species metabolic process
liver regeneration
negative regulation of calcium import into the mitochondrion
positive regulation of cold-induced thermogenesis
oxaloacetate(2-) transmembrane transport
sulfate transmembrane transport
chloride transmembrane transport
hydrogen ion transmembrane transport
mitochondrial transmembrane transport
adaptive thermogenesis
female pregnancy
aging
positive regulation of cell death
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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