May serve as a "flippase" as well as a glucosyltransferase that transfers glucose to ceramide. It Catalzes; UDP-glucose + Nacylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
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Protein Aliases: Ceramide glucosyltransferase; GCS; GLCT-1; GLCT1; Glucosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
Gene Aliases: GCS; GLCT1; UGCG
UniProt ID: (Human) Q16739
Entrez Gene ID: (Human) 7357