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Invitrogen
UNG2 Polyclonal Antibody
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Product Details
PA5-34551
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide near the amino terminus of human UNG2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is NIH-3T3 cell lysate.
PA5-34551 can be used with blocking peptide PEP-1594.
Target Information
The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: UDG; UDG2; UNG; Uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase nuclear isoform
Gene Aliases: DGU; HIGM4; HIGM5; UDG; UNG; UNG1; UNG15; UNG2
UniProt ID: (Human) P13051, (Mouse) P97931
Entrez Gene ID: (Human) 7374, (Mouse) 22256
damaged DNA binding
uracil DNA N-glycosylase activity
protein binding
enzyme binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
uridine nucleosidase activity
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
DNA repair
base-excision repair
viral process
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
negative regulation of apoptotic process
depyrimidination
positive regulation of isotype switching
base-excision repair, AP site formation via deaminated base removal
cellular response to DNA damage stimulus
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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