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YY1 Polyclonal Antibody
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FIGURE: 1 / 5
YY1 Antibody (61779) in IHC (P)
YY1 antibody (pAb) tested by Immunohistochemistry. Nuclear staining pattern is detected in Formalin-fixed, paraffin-embedded tissue sections from human adenocarcinoma. Top Panel: YY1 antibody at 1:1,000 dilution. Bottom Panel: No primary antibody (2nd step antibody alone).
Product Details
61779
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was raised against a recombinant protein corresponding to amino acids 249-414 of human YY1.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Antigen affinity chromatography, Affinity chromatography
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Delta transcription factor; INO80 complex subunit S; NF-E1; Transcriptional repressor protein YY1; Yin and yang 1; Yin and Yang 1 protein; YY-1
Gene Aliases: DELTA; GADEVS; INO80S; NF-E1; UCRBP; YIN-YANG-1; YY1
UniProt ID: (Human) P25490
Entrez Gene ID: (Human) 7528
four-way junction DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
SMAD binding
metal ion binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
double-strand break repair via homologous recombination
regulation of DNA replication
DNA repair
regulation of DNA repair
DNA recombination
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
RNA localization
cellular response to DNA damage stimulus
spermatogenesis
anterior/posterior pattern specification
response to UV-C
gene expression
positive regulation of gene expression
negative regulation of gene expression
hemopoiesis
cell differentiation
B cell differentiation
negative regulation of interferon-beta production
regulation of chromosome organization
cellular response to UV
response to prostaglandin F
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
camera-type eye morphogenesis
chromosome organization
regulation of cell cycle
regulation of DNA strand elongation
negative regulation of cell growth involved in cardiac muscle cell development
cellular response to interleukin-1
immunoglobulin heavy chain V-D-J recombination
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of telomere maintenance in response to DNA damage
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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