Immunogen sequence: PQDIECCGAL EYYDKAFDRI TTRSEKPLRS IKRIFHTVTT TDDPVIRKLA KTQGNVFATD AILATLMSCT RSVYSWDI
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
eIF3D is a protein belonging to the largest of the eukaryotic translation initiation factor family, eukaryotic translation initiation factor-3 (eIF3). eIF3 is a multiprotein complex composed of at least 13 different subunits. eIF3D binds to the 40S ribosomal subunit and thus helps in maintaining the 40S and 60S ribosomal subunits in a dissociated state. An important role of eIF3D is the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and promotes mRNA binding. eIF3D is the major RNA binding subunit of the eIF3 complex. It associates with the subunit p170 of eIF-3. Ubiquitous expression of eIF3D is seen in most of the tissues and it is phosphorylated upon DNA damage, likely by ATM or ATR.
Protein Aliases: eIF-3-zeta; eIF3 p66; EIF3D; Eukaryotic translation initiation factor 3 subunit 7; Eukaryotic translation initiation factor 3 subunit D; eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa; eukaryotic translation initiation factor 3, subunit D; RP5-1119A7.12-003; translation initiation factor eIF3 p66 subunit
Gene Aliases: eIF3-p66; eIF3-zeta; EIF3D; EIF3S7
UniProt ID: (Human) O15371
Entrez Gene ID: (Human) 8664
Molecular Function: translation initiation factor