Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
55014-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
The antibody is specific to NGFR.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 neurotrophin receptor; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Aliases: CD271; Gp80-LNGFR; LNGFR; NGFR; p75; p75(NTR); p75NGFR; p75NTR; RNNGFRR; TNFRSF16
UniProt ID: (Human) P08138, (Rat) P07174, (Mouse) Q9Z0W1
Entrez Gene ID: (Human) 4804, (Rat) 24596, (Mouse) 18053
Molecular Function:
transmembrane signal receptor
intracellular protein transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
axon guidance
response to wounding
negative regulation of neuron projection development
sensory perception of pain
membrane protein intracellular domain proteolysis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
regulation of cell proliferation
glucose homeostasis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
negative regulation of axonogenesis
positive regulation of axonogenesis
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
apoptotic signaling pathway
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
regulation of glucose import in response to insulin stimulus
apoptotic process
signal transduction
central nervous system development
regulation of gene expression
positive regulation of cell death
programmed cell death
detection of temperature stimulus
nerve development
hair follicle morphogenesis
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of odontogenesis of dentin-containing tooth
skin development
positive regulation of fibroblast proliferation
negative regulation of hair follicle development
negative regulation of cell death
positive regulation of apoptotic signaling pathway
multicellular organism development
nervous system development
cell differentiation
rhythmic process
beta-amyloid binding
signal transducer activity
receptor activity
transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity
neurotrophin TRKA receptor binding
protein binding
Rab GTPase binding
ubiquitin protein ligase binding
nerve growth factor binding
preprotein binding
death receptor activity
neurotrophin binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support