CD300 antigen like family member E, CD300 antigen-like family member E, CD300e, CD300e antigen, CLM-2, CMRF35-A5, CMRF35-like molecule 2, Immune receptor expressed on myeloid cells 2, IREM-2, PIgR-2, poly-Ig receptor 2, Polymeric immunoglobulin receptor 2
Human CD300e/LMIR6 quantitates human CD300e/LMIR6 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD300e/LMIR6.
CD300e is a member of the glycoprotein family of cell surface proteins expressed on myeloid cells. CD300e interacts with the TYRO protein tyrosine kinase-binding protein and is thought to be involved as an activating receptor. CD300e is expressed on mature myeloid dendritic cells and monocytes, and is down regulated on immature dendritic cells. Further, CD300e interacts with DAP-12, which mediates activating signals. The alloreactive response of naïve T cells has been reported to become enhanced by the activation of CD300e. Diseases associated with CD300e dysfunction include tungiasis and lice infestation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.