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Proteintech
CDC37 Polyclonal Antibody
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Product Details
10218-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDC37 Fusion Protein Ag0267 (1-209 aa encoded by BC000083)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVDYSVWDH IEVSDDEDET HPNIDTASLF RWRHQARVER MEQFQKEKEE LDRGCRECKR KVAECQRKLK ELEVAEGGKA ELERLQAEAQ QLRKEERSWE QKLEEMRKKE KSMPWNVDTL SKDGFSKSMV NTKPEKTEED SEEVREQKHK TFVEKYEKQI KHFGMLRRWD DSQKYLSDNV HLVCEETANY LVIWCIDLEV EEKCALMEQV (1-209 aa encoded by BC000083)
Target Information
In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDC 37; CDC37; CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; cell division cycle 37 homolog; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50Cdc37
Gene Aliases: CDC37; CDC37A; p50; P50CDC37
UniProt ID: (Human) Q16543, (Mouse) Q61081
Entrez Gene ID: (Human) 11140, (Mouse) 12539
protein binding
protein kinase regulator activity
kinase binding
protein kinase binding
heat shock protein binding
unfolded protein binding
chaperone binding
Hsp90 protein binding
scaffold protein binding
protein C-terminus binding
mitogen-activated protein kinase kinase kinase binding
protein kinase B binding
chaperone
regulation of cyclin-dependent protein serine/threonine kinase activity
protein folding
protein targeting
posttranscriptional regulation of gene expression
protein stabilization
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
positive regulation of type 2 mitophagy
regulation of protein kinase activity
mitophagy in response to mitochondrial depolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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