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Proteintech
Islet 1 Polyclonal Antibody
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Product Details
15661-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Islet 1 Fusion Protein Ag8088 (1-349 aa encoded by BC031213)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGDMGDPPK KKRLISLCVG CGNQIHDQYI LRVSPDLEWH AACLKCAECN QYLDESCTCF VRDGKTYCKR DYIRLYGIKC AKCSIGFSKN DFVMRARSKV YHIECFRCVA CSRQLIPGDE FALREDGLFC RADHDVVERA SLGAGDPLSP LHPARPLQMA AEPISARQPA LRPHVHKQPE KTTRVRTVLN EKQLHTLRTC YAANPRPDAL MKEQLVEMTG LSPRVIRVWF QNKRCKDKKR SIMMKQLQQQ QPNDKTNIQG MTGTPMVAAS PERHDGGLQA NPVEVQSYQP PWKVLSDFAL QSDIDQPAFQ QLVNFSEGGP GSNSTGSEVA SMSSQLPDTP NSMVASPIEA (1-349 aa encoded by BC031213)
Target Information
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeobox; Insulin gene enhancer protein ISL-1; Islet-1; unnamed protein product
Gene Aliases: Isl-1; ISL1; ISLET1
UniProt ID: (Human) P61371
Entrez Gene ID: (Human) 3670
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
protein binding
ligand-dependent nuclear receptor binding
LIM domain binding
estrogen receptor binding
bHLH transcription factor binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
heart morphogenesis
secondary heart field specification
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
regulation of secondary heart field cardioblast proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
axonogenesis
heart development
cell proliferation
positive regulation of cell proliferation
regulation of gene expression
positive regulation of vascular endothelial growth factor production
positive regulation of epithelial to mesenchymal transition
spinal cord motor neuron cell fate specification
spinal cord motor neuron differentiation
visceral motor neuron differentiation
trigeminal nerve development
pituitary gland development
cell differentiation
neuron differentiation
pancreas development
axon regeneration
retinal ganglion cell axon guidance
negative regulation of protein complex assembly
positive regulation of insulin secretion
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of angiogenesis
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
neuron fate specification
mesenchymal cell differentiation
stem cell differentiation
sensory system development
peripheral nervous system neuron development
peripheral nervous system neuron axonogenesis
negative regulation of epithelial cell proliferation
negative regulation of inflammatory response
ventricular cardiac muscle tissue morphogenesis
pharyngeal system development
canonical Wnt signaling pathway
cardiac muscle cell myoblast differentiation
innervation
atrial septum morphogenesis
cardiac cell fate determination
sinoatrial node cell development
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of granulocyte colony-stimulating factor production
negative regulation of mesenchymal cell proliferation
regulation of heart rate by cardiac conduction
negative regulation of canonical Wnt signaling pathway
positive regulation of calcium ion import
positive regulation of macrophage colony-stimulating factor production
positive regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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