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NeoBiotechnologies
PAX2 (Renal Cell and Ovarian Carcinoma Marker) Monoclonal Antibody (PAX2/1105)
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FIGURE: 1 / 3
PAX2 (Renal Cell and Ovarian Carcinoma Marker) Antibody (5076-MSM2-P0) in IHC (P)
Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with PAX2 Recombinant Mouse Monoclonal Antibody (rPAX2/8506) at 2 µg/mL. HIER: Tris/EDTA, pH9.0, 45 min. 2 °: HRP-polymer, 30 min. DAB, 5 min.
Product Details
5076-MSM2-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
PAX2/1105
Immunogen
Recombinant fragment (around aa 223-354) of human PAX2 protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: paired box homeotic gene 2; Paired box protein Pax-2
Gene Aliases: FSGS7; PAPRS; PAX-2; PAX2
UniProt ID: (Human) Q02962
Entrez Gene ID: (Human) 5076
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific double-stranded DNA binding
urogenital system development
branching involved in ureteric bud morphogenesis
cell fate determination
mesonephros development
neural tube closure
optic cup morphogenesis involved in camera-type eye development
mesenchymal to epithelial transition involved in metanephros morphogenesis
retinal pigment epithelium development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
axonogenesis
sensory organ development
mesodermal cell fate specification
visual perception
glial cell differentiation
optic nerve development
optic nerve morphogenesis
optic nerve structural organization
vestibulocochlear nerve formation
cell differentiation
regulation of metanephros size
ureter maturation
pronephric field specification
inner ear morphogenesis
camera-type eye development
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
animal organ development
system development
pronephros development
brain morphogenesis
stem cell differentiation
positive regulation of epithelial cell proliferation
mesenchymal to epithelial transition
optic chiasma development
cellular response to retinoic acid
cellular response to glucose stimulus
metanephric mesenchyme development
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
metanephric mesenchymal cell differentiation
nephric duct formation
ureter development
metanephric collecting duct development
metanephric epithelium development
metanephric distal convoluted tubule development
metanephric nephron tubule formation
positive regulation of metanephric glomerulus development
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
cochlea development
cochlea morphogenesis
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
negative regulation of apoptotic process involved in metanephric collecting duct development
negative regulation of apoptotic process involved in metanephric nephron tubule development
negative regulation of reactive oxygen species metabolic process
positive regulation of metanephric DCT cell differentiation
positive regulation of optic nerve formation
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