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Proteintech
SIRT4 Monoclonal Antibody (1D5A2)
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Product Details
66543-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Published species
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1D5A2
Immunogen
SIRT4 Fusion Protein Ag17347 (1-314 aa encoded by BC109319)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKMSFALTF RSAKGRWIAN PSQPCSKASI GLFVPASPPL DPEKVKELQR FITLSKRLLV MTGAGISTES GIPDYRSEKV GLYARTDRRP IQHGDFVRSA PIRQRYWARN FVGWPQFSSH QPNPAHWALS TWEKLGKLYW LVTQNVDALH TKAGSRRLTE LHGCMDRVLC LDCGEQTPRG VLQERFQVLN PTWSAEAHGL APDGDVFLSE EQVRSFQVPT CVQCGGHLKP DVVFFGDTVN PDKVDFVHKR VKEADSLLVV GSSLQVYSGY RFILTAWEKK LPIAILNIGP TRSDDLACLK LNSRCGELLP LIDPC (1-314 aa encoded by BC109319)
Target Information
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC130046; MGC130047; MGC57437; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Regulatory protein SIR2 homolog 4; sir2-like 4; SIR2-like protein 4; sirtuin type 4; yeast silent information regulator 2 (Sir2p) homolog; similar to prokaryotic sirtuins
Gene Aliases: 4930596O17Rik; SIR2L4; SIRT4
UniProt ID: (Human) Q9Y6E7, (Mouse) Q8R216
Entrez Gene ID: (Pig) 100125349, (Human) 23409, (Mouse) 75387, (Rat) 304539
NAD+ ADP-ribosyltransferase activity
histone deacetylase activity
protein binding
zinc ion binding
transferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
transferase activity, transferring glycosyl groups
nucleotidyltransferase activity
NAD-dependent protein deacetylase activity
metal ion binding
NAD binding
lipoamidase activity
NAD+ binding
NAD-dependent protein lipoamidase activity
NAD-dependent protein biotinidase activity
NAD+-protein-cysteine ADP-ribosyltransferase activity
protein ADP-ribosylase activity
imidazoleglycerol-phosphate synthase activity
protein-N-terminal asparagine amidohydrolase activity
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hydrolase activity
NAD(P)-cysteine ADP-ribosyltransferase activity
NAD(P)-asparagine ADP-ribosyltransferase activity
NAD(P)-serine ADP-ribosyltransferase activity
iprodione amidohydrolase activity
(3,5-dichlorophenylurea)acetate amidohydrolase activity
4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
didemethylisoproturon amidohydrolase activity
N-isopropylacetanilide amidohydrolase activity
N-cyclohexylformamide amidohydrolase activity
isonicotinic acid hydrazide hydrolase activity
cis-aconitamide amidase activity
gamma-N-formylaminovinylacetate hydrolase activity
N2-acetyl-L-lysine deacetylase activity
O-succinylbenzoate synthase activity
indoleacetamide hydrolase activity
7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
N-acetylcitrulline deacetylase activity
purine deoxyribosyltransferase activity
N-acetylgalactosamine-6-phosphate deacetylase activity
diacetylchitobiose deacetylase activity
chitooligosaccharide deacetylase activity
molecular_function
protein ADP-ribosylation
glutamine metabolic process
cellular response to DNA damage stimulus
negative regulation of cardiac muscle cell apoptotic process
peptidyl-lysine deacetylation
negative regulation of fatty acid oxidation
negative regulation of insulin secretion
positive regulation of lipid biosynthetic process
tricarboxylic acid metabolic process
negative regulation of protein processing involved in protein targeting to mitochondrion
cellular response to hypoxia
regulation of glutamine family amino acid metabolic process
mitochondrion organization
negative regulation of pyruvate decarboxylation to acetyl-CoA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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