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Invitrogen
S100B Recombinant Rabbit Monoclonal Antibody (16H24L21)
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FIGURE: 1 / 5
S100B Antibody (701340) in IHC (P)
Immunohistochemistry analysis of S100 beta showing staining in the cytoplasm and nucleus of paraffin-embedded mouse brain tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10 mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room... View More
Product Details
701340
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
16H24L21
Immunogen
Peptide corresponding to amino acids 18-40 of human S100B
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with non-human primate and rabbit based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein beta (neural); S100 calcium-binding protein, beta (neural); S100 protein beta chain; S100 protein, beta polypeptide, neural; S100B
Gene Aliases: AI850290; Bpb; NEF; S100; S100-B; S100B; S100beta; S100P
UniProt ID: (Human) P04271, (Mouse) P50114, (Rat) P04631
Entrez Gene ID: (Human) 6285, (Mouse) 20203, (Rat) 25742
cell adhesion
axonogenesis
central nervous system development
learning or memory
memory
positive regulation of cell proliferation
regulation of cell shape
positive regulation of myelination
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of neuron differentiation
regulation of neuronal synaptic plasticity
astrocyte differentiation
positive regulation of synaptic transmission
response to glucocorticoid
response to methylmercury
long-term synaptic potentiation
cellular response to hypoxia
response to anesthetic
sympathetic neuron projection extension
neuron projection extension
adaptive thermogenesis
negative regulation of skeletal muscle cell differentiation
energy reserve metabolic process
cellular calcium ion homeostasis
regulation of cytokine biosynthetic process
regulation of long-term neuronal synaptic plasticity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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