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Invitrogen

HTR2C Polyclonal Antibody

View all (21) HTR2C antibodies

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HTR2C Polyclonal Antibody

Product Details

720264

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Protein corresponding to Human HTR2C (aa 236-311)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2-7.4, with 0.1% BSA, 30% glycerol

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2633225

Product Specific Information

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Horse, Pig, Goat, Cat and Rabbit

Target Information

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5-HT1c receptor; 5-HT2C receptor; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5HT2C Receptor; HGNC:5295; RP11-810O3.1; RP23-15B7.1; serotonin; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor; serotonin receptor 2C; unnamed protein product

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Gene Aliases: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT1c; 5HTR2C; HTR1C; SR1

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UniProt ID: (Human) P28335, (Mouse) P34968

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Entrez Gene ID: (Human) 3358, (Mouse) 15560

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Function(s)
Gq/11-coupled serotonin receptor activity G-protein coupled receptor activity G-protein coupled serotonin receptor activity protein binding neurotransmitter receptor activity identical protein binding serotonin binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding serotonin receptor activity
Process(es)
behavioral fear response cellular calcium ion homeostasis G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission locomotory behavior feeding behavior positive regulation of phosphatidylinositol biosynthetic process regulation of neurological system process regulation of appetite regulation of corticotropin-releasing hormone secretion release of sequestered calcium ion into cytosol positive regulation of ERK1 and ERK2 cascade G protein-coupled serotonin receptor signaling pathway response to xenobiotic stimulus positive regulation of gamma-aminobutyric acid secretion positive regulation of acetylcholine secretion, neurotransmission phospholipase D-activating G-protein coupled receptor signaling pathway behavioral response to nicotine positive regulation of fat cell differentiation positive regulation of vasoconstriction negative regulation of dopamine metabolic process sensitization positive regulation of calcium-mediated signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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