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Bethyl Laboratories
TAB3 Polyclonal Antibody
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FIGURE: 1 / 2
TAB3 Antibody (A302-207A) in WB
Detection of human and mouse TAB3 by western blot. Samples: Whole cell lysate (50, 15 µg) from HEK293T and (50 µg) from HeLa and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-TAB3 antibody (Product # A302-207A) (lot A302-207A-2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A302-207A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 600 and 650 of Human TAK1 binding protein 3 (mitogen-activated protein kinase kinase kinase 7 interacting protein 3).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitogen activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAB3; ortholog of Xenopus laevis TAB3; TAB3a; ortholog of Xenopus laevis TAB3; TAK1-binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3; unnamed protein product
Gene Aliases: 4921526G09Rik; Kiaa4135; MAP3K7IP3; mKIAA4135; NAP1; TAB3
UniProt ID: (Human) Q8N5C8, (Mouse) Q571K4
Entrez Gene ID: (Human) 257397, (Mouse) 66724
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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