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Bethyl Laboratories
MIER3 Polyclonal Antibody
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FIGURE: 1 / 2
MIER3 Antibody (A303-194A) in WB
Detection of human MIER3 by western blot. Samples: Whole cell lysate (25 µg) from Jurkat, HEK293T, HeLa, RKO, and LNCaP cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-MIER3 antibody (Product # A303-194A lot 2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 75 seconds.
Product Details
A303-194A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 400 and 450 of human Mesoderm Induction Early Response 1, Family Member 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
MIER3, known as Mesoderm Induction Early Response 1, Family Member 3, is a gene associated with epithelial-mesenchymal transition (EMT) processes particularly in cancer research. The gene is located on chromosome 7 and has been identified in studies as playing a crucial role in the progression of colorectal and breast cancers. Structurally, MIER3 is involved in chromatin remodeling and histone acetylation, functioning together with HDAC1/2 and Snail proteins. Its expression profile has been characterized using bioinformatics, real-time PCR, and Western blotting, indicating that MIER3 interacts closely with cellular mechanisms that modulate gene expression and cellular differentiation. The gene's role in cancer has been explored through its capacity to induce EMT, which affects tumor metastasis and cell migration, highlighting its potential as a therapeutic target in oncology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mesoderm induction early response 1, family member 3; Mesoderm induction early response protein 3; Mi-er3; unnamed protein product
Gene Aliases: MIER3
UniProt ID: (Human) Q7Z3K6
Entrez Gene ID: (Human) 166968
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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