Search
Bethyl Laboratories
PLZF Recombinant Rabbit Monoclonal Antibody (BLR336M)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
A700-336CF
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR336M
Immunogen
Recombinant antibody was purified from cell culture supernatant. Immunogen was a recombinant protein representing human zinc finger and BTB domain-containing protein 16 (aka PLZF, residues 6-126, NP_005997.2).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 6.8-7.4
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: promyelocytic leukaemia zinc finger; Promyelocytic leukemia zinc finger protein; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); Zinc finger protein PLZF
Gene Aliases: PLZF; ZBTB16; ZNF145
UniProt ID: (Human) Q05516
Entrez Gene ID: (Human) 7704
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
protein domain specific binding
type 2 angiotensin receptor binding
identical protein binding
protein homodimerization activity
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
mesonephros development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
central nervous system development
cell proliferation
negative regulation of cell proliferation
embryonic pattern specification
anterior/posterior pattern specification
regulation of gene expression
positive regulation of macromolecule biosynthetic process
protein ubiquitination
hemopoiesis
myeloid cell differentiation
positive regulation of chondrocyte differentiation
protein localization to nucleus
embryonic hindlimb morphogenesis
forelimb morphogenesis
hindlimb morphogenesis
embryonic digit morphogenesis
positive regulation of apoptotic process
ossification involved in bone maturation
regulation of cell differentiation
positive regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of ossification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
male germ-line stem cell asymmetric division
positive regulation of NK T cell differentiation
cartilage development
positive regulation of multicellular organismal process
positive regulation of cartilage development
regulation of multicellular organismal development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support