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Alomone Labs, LTD
Kir2.2 (KCNJ12) Polyclonal Antibody
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FIGURE: 1 / 2
Kir2.2 (KCNJ12) Antibody (APC-042-50UL) in IHC (F)
Expression ofKir2.2in ratcerebellum. Immunohistochemicalstaining of perfusion-fixed frozenratbrainsections with Anti-Kir2.2 (KCNJ12) Antibody &(8)239; (#APC-042), (1:300), followed by goat Anti-rabbit-AlexaFluor-488. A.Kir2.2immunoreactivity (green)appeared inBergmann glial fibers (right-pointing arrows) and outlines of molecular layer neurons (left-pointing arrows).B. Pre-incubation of the Antibody with Ki... View More
Product Details
APC-042-50UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)EVATDRDGRSPQPEHDFDR,corresponding to amino acid residues 391-409 of rat Kir2.2, Intracellular, C-terminal domain
Conjugate
Form
Lyophilized
Concentration
0.39 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+) channel Kir2.2; Inward rectifier K(+) channel Kir2.2v; IRK-2; Potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly-rectifying channel, subfamily J, member 12; potassium voltage-gated channel subfamily J member 12
Gene Aliases: hIRK; hIRK1; hkir2.2x; IRK-2; IRK2; KCNJ12; kcnj12x; KCNJN1; Kir2.1; Kir2.2; MB-IRK2
UniProt ID: (Human) Q14500, (Mouse) P52187
Entrez Gene ID: (Human) 3768, (Mouse) 16515, (Rat) 117052
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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