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Invitrogen

CD105 Monoclonal Antibody (MEM-226), FITC

8 Published Figures
13 References
View all (113) CD105 (Endoglin) antibodies

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Product Details

MA1-19594

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

20 µL/1x10^6 cells
View 13 publications 13 publications
Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

MEM-226

Immunogen

Recombinant vaccinia virus containing the human CD105 cDNA.

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.03 mg/mL

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1071125

Product Specific Information

This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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Bioinformatics

Protein Aliases: CD105; CD105 antigen; circulating isoform of endoglin TGF-beta receptor type III; Endoglin; endoglin precursor; ORW; soluble endoglin; unnamed protein product

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Gene Aliases: END; ENG; HHT1; ORW1

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UniProt ID: (Human) P17813

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Entrez Gene ID: (Human) 2022, (Rat) 497010

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Function(s)
transmembrane signaling receptor activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding coreceptor activity receptor activator activity type I transforming growth factor beta receptor binding BMP binding identical protein binding protein homodimerization activity activin binding transforming growth factor beta binding transforming growth factor beta-activated receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity transmembrane signal receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis patterning of blood vessels vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation heart looping sprouting angiogenesis positive regulation of systemic arterial blood pressure outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion transforming growth factor beta receptor signaling pathway heart development negative regulation of gene expression regulation of cardiac muscle cell apoptotic process cell migration regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis extracellular matrix disassembly regulation of cell adhesion negative regulation of cell migration BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of BMP signaling pathway dorsal aorta morphogenesis wound healing regulation of cell proliferation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis cell motility positive regulation of protein kinase B signaling atrial cardiac muscle tissue morphogenesis cell chemotaxis positive regulation of SMAD protein import into nucleus negative regulation of SMAD protein import into nucleus detection of hypoxia endocardial cushion to mesenchymal transition vascular smooth muscle cell development positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of vascular smooth muscle cell differentiation atrioventricular canal morphogenesis regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis regulation of cell proliferation involved in heart morphogenesis chronological cell aging positive regulation of protein phosphorylation transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of protein autophosphorylation response to corticosteroid positive regulation of collagen biosynthetic process intracellular signal transduction response to statin negative regulation of nitric-oxide synthase activity bone development negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion cellular response to mechanical stimulus response to transforming growth factor beta
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