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Invitrogen

CD3/CD20 Antibody Cocktail

View all (10) CD3/CD20 antibodies

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Product Details

MA5-14433

Applications
Tested Dilution
Publications

Western Blot (WB)

Neat-1:100
-

Immunohistochemistry (Paraffin) (IHC (P))

Neat
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mixed / IgG2a, kappa

Class

Cocktail

Type

Antibody

Clone

CD3-SP7; CD20-L26

Immunogen

synthetic 13-mer peptide corresponding to aa 156-168 of the epsilon chain of human CD3 protien; CD20- Human tonsil B cells

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

tris HCl, pH 7.6, with proprietary stabilizer

Contains

<0.1% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986449

Product Specific Information

MA5-14433 targets CD3/CD20 in IHC (P) and WB applications and shows reactivity with Human, Mouse and Rat samples. CD3 (clone SP7) is a rabbit monoclonal IgG antibody. CD20 (clone L26) is an IgG2a mouse monoclonal antibody.

The MA5-14433 immunogen is synthetic 13-mer peptide corresponding to aa 156-168 of the epsilon chain of human CD3 protein; the CD20 immunogen is human tonsil B cells.

Target Information

The CD3 antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by normal and neoplastic T-lymphocytes. It stains human T-lymphocytes in both cortex and medulla of the thymus and in peripheral lymphoid tissues. CD20 is a non-Ig differentiation antigen of B-lymphocytes and the expression of CD20 is restricted to normal and neoplastic B-lymphocytes, being absent from all other leukocytes and tissues. The CD3-CD20 cocktail reveals lymphoid architecture in neoplastic situations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-cell differentiation antigen Ly-44; B-lymphocyte cell-surface antigen B1; CD20 antigen; CD20 receptor; CD3 antigen delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 delta; CD3 gamma-chain; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma polypeptide; CD3-epsilon; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); leukocyte surface antigen Leu-16; lymphocyte antigen 44; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; Ms4a1; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T3-epsilon protein; unnamed protein product

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Gene Aliases: B1; Bp35; CD20; CD3; CD3-DELTA; CD3-GAMMA; CD3DELTA; CD3epsilon; CD3GAMMA; Ctg-3; Ctg3; CVID5; FMC7; IMD17; IMD18; IMD19; LEU-16; Ly-44; Ms4a2; S7; T3D; T3E; T3G; TCRE

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UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Mouse) P04235, (Rat) P19377, (Mouse) P22646, (Rat) Q64159, (Mouse) P11942, (Human) P11836, (Mouse) P19437

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Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Mouse) 12500, (Rat) 25710, (Mouse) 12501, (Rat) 315609, (Rat) 300678, (Mouse) 12502, (Human) 931, (Mouse) 12482, (Rat) 309217

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Function(s)
transmembrane signaling receptor activity protein binding MHC class II receptor activity identical protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity protein binding, bridging T cell receptor binding epidermal growth factor receptor binding immunoglobulin binding MHC class II protein complex binding
Process(es)
store-operated calcium entry cell surface receptor signaling pathway response to bacterium B cell differentiation B cell activation B cell receptor signaling pathway protein tetramerization calcium ion import into cytosol positive regulation of calcium ion import across plasma membrane positive regulation of cell-matrix adhesion positive regulation of T cell anergy response to nutrient regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin positive regulation of T cell proliferation positive regulation of MAPK cascade positive thymic T cell selection negative thymic T cell selection negative regulation of smoothened signaling pathway positive regulation of alpha-beta T cell proliferation lymphocyte activation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of calcium-mediated signaling T cell receptor signaling pathway positive regulation of T cell activation apoptotic signaling pathway establishment or maintenance of cell polarity biological_process protein transport regulation of lymphocyte apoptotic process T cell activation protein-containing complex assembly adaptive immune response alpha-beta T cell activation gamma-delta T cell activation humoral immune response B cell proliferation transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway regulation of apoptotic process T cell differentiation in thymus
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