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Invitrogen
LPL Recombinant Rabbit Monoclonal Antibody (10E10P9)
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FIGURE: 1 / 4
LPL Antibody (MA5-35444) in WB
Western blot was performed using LPL Recombinant Rabbit Monoclonal Antibody (ARC0904) (Product # MA5-35444) and a 52 kDa band corresponding to LPL was observed across HeLa and THP-1. Downregulation of LPL was seen in HeLa cells treated with 50 µM of Atorvastatin for 24h. Whole cell extracts (30 µg lysate) of HeLa (Lane 1), HeLa treated with 50 µM of Atorvastatin for 24h. (Lane 2), THP-1 (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX), 10 well. Resolved proteins were then transferred onto a nitro... View More
Product Details
MA5-35444
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10E10P9
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IPFTLPEVST NKTYSFLIYT EVDIGELLML KLKWKSDSYF SWSDWWSSPG FAIQKIRVKA GETQKKVIFC SREKVSHLQK GKAPAVFVKC HDKSLNKKSG
Target Information
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha lipase; Lipoprotein lipase; lipoprotein lipase precursor; LPL; O 1-4-5; Phospholipase A1; unnamed protein product
Gene Aliases: HDLCQ11; LIPD; LPL
UniProt ID: (Human) P06858, (Mouse) P11152
Entrez Gene ID: (Human) 4023, (Mouse) 16956
lipoprotein lipase activity
phospholipase activity
triglyceride lipase activity
receptor binding
calcium ion binding
protein binding
heparin binding
phosphatidylcholine 1-acylhydrolase activity
lipase activity
hydrolase activity
apolipoprotein binding
protein homodimerization activity
heparan sulfate proteoglycan binding
protein anchor
metal ion binding
carboxylic ester hydrolase activity
lipoprotein particle binding
triglyceride binding
lipase
retinoid metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
triglyceride metabolic process
phospholipid metabolic process
response to bacterium
response to glucose
positive regulation of macrophage derived foam cell differentiation
positive regulation of lipid storage
positive regulation of cholesterol storage
lipid catabolic process
triglyceride catabolic process
cellular response to nutrient
positive regulation of chemokine production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
chylomicron remodeling
very-low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle clearance
cholesterol homeostasis
positive regulation of fat cell differentiation
positive regulation of inflammatory response
low-density lipoprotein particle mediated signaling
triglyceride homeostasis
cellular response to fatty acid
positive regulation of adipose tissue development
positive regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of sequestering of triglyceride
triglyceride biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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