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Invitrogen
BMP6 Monoclonal Antibody (D2)
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FIGURE: 1 / 3
BMP6 Antibody (MA5-51039) in IHC (P)
Immunohistochemistry (Paraffin) analysis of BMP6 in human kidney tissue using BMP6 Monoclonal Antibody (D2) (Product # MA5-51039) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Mouse IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-51039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
D2
Immunogen
Recombinant Human BMP6 protein, Ser375-His513 (Accession #P22004)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 6; Bone morphogenetic protein; unnamed protein product; vegetal related growth factor (TGFB-related); VG-1-R; VG-1-related protein
Gene Aliases: IO; VGR; VGR1
UniProt ID: (Human) P22004
Entrez Gene ID: (Human) 654, (Pig) 100155536
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
ossification
osteoblast differentiation
eye development
kidney development
positive regulation of endothelial cell proliferation
type B pancreatic cell development
cellular iron ion homeostasis
inflammatory response
immune response
heart development
positive regulation of cell proliferation
tissue development
response to iron ion
positive regulation of gene expression
response to activity
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of lipopolysaccharide-mediated signaling pathway
response to magnesium ion
positive regulation of chondrocyte differentiation
positive regulation of aldosterone biosynthetic process
response to retinoic acid
regulation of cell proliferation
positive regulation of vascular permeability
positive regulation of endothelial cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
positive regulation of developmental process
response to glucocorticoid
bone development
positive regulation of SMAD protein import into nucleus
multicellular organismal iron ion homeostasis
cellular response to mechanical stimulus
cellular response to iron ion
cellular response to BMP stimulus
positive regulation of intracellular signal transduction
negative regulation of adherens junction organization
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of aldosterone secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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