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Invitrogen
JNK3 Recombinant Rabbit Monoclonal Antibody (24GB320)
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FIGURE: 1 / 4
JNK3 Antibody (MA5-57460) in ICC/IF
Immunocytochemical staining of JNK3 in HT-1080 cells using JNK3 Recombinant Monoclonal Antibody (Product # MA5-57460) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; JNK3 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57460
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB320
Immunogen
A synthesized peptide derived from human JNK3 (aa 410-464)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 3; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; p54-beta; SAPK-beta; SAPK/Erk/kinase 2; Stress activated protein kinase beta; stress-activated protein kinase 1b; stress-activated protein kinase JNK3; unnamed protein product
Gene Aliases: C230008H04Rik; JNK3; JNK3A; JNK3B1; JNK3B2; p493F12; p54bSAPK; PRKM10; SAPb; SAPK(beta); SAPK1b; SAPKC; Serk2
UniProt ID: (Human) P53779, (Mouse) Q61831, (Rat) P49187
Entrez Gene ID: (Human) 5602, (Mouse) 26414, (Rat) 25272
MAPK cascade
protein phosphorylation
signal transduction
JNK cascade
response to light stimulus
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
cellular senescence
negative regulation of transcription from RNA polymerase II promoter
JUN phosphorylation
locomotor rhythm
neurotransmitter receptor transport to postsynaptic membrane
vesicle-mediated transport in synapse
cellular hyperosmotic response
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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