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Invitrogen
Caspase 1 Polyclonal Antibody
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FIGURE: 1 / 3
Caspase 1 Antibody (PA1-41214) in IHC (P)
Immunohistochemical analysis of Caspase 1 in Human reactive lymph node. Samples were incubated in Caspase 1 polyclonal antibody (Product # PA1-41214) followed by a DAB chromogen and Hematoxylin counterstain. B is a higher magnification of A. Staining in macrophages is observed.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-41214
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an internal portion of the human Caspase-1 protein (between amino acids 15-60).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: antigen standard for CASP1 (transient overexpression lysate), Hela whole cell extract.
Porcine/Rabbit (85%) and Canine (70%).
Target Information
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1-b and IL-18. Caspase-1 was initially identified as an IL-1-b-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase1; cysteine protease; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45; unnamed protein product
Gene Aliases: ICE; IL1BC; P45
UniProt ID: (Human) P29466, (Mouse) P29452
Entrez Gene ID: (Human) 834, (Mouse) 12362, (Rat) 25166
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
enzyme binding
kinase binding
cytokine binding
identical protein binding
CARD domain binding
peptidase activity
scaffold protein binding
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
microglial cell activation
plasma membrane repair
positive regulation of cytokine production
pattern recognition receptor signaling pathway
proteolysis
inflammatory response
osmosensory signaling pathway
myoblast fusion
memory
protein secretion
response to xenobiotic stimulus
response to bacterium
regulation of autophagy
programmed cell death
protein processing
protein autoprocessing
protein catabolic process
response to lipopolysaccharide
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-18 production
response to ATP
interleukin-18-mediated signaling pathway
defense response to bacterium
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of circadian sleep/wake cycle, non-REM sleep
ceramide biosynthetic process
regulation of inflammatory response
positive regulation of inflammatory response
defense response to Gram-negative bacterium
protein maturation
defense response to virus
mitochondrial depolarization
membrane hyperpolarization
protein poly-ADP-ribosylation
pyroptosis
interleukin-1-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to interferon-gamma
programmed necrotic cell death
cytokine precursor processing
signaling receptor ligand precursor processing
AIM2 inflammasome complex assembly
pyroptotic cell death
positive regulation of NLRP3 inflammasome complex assembly
response to paraquat
positive regulation of tumor necrosis factor-mediated signaling pathway
apoptotic process
signal transduction
positive regulation of neuron apoptotic process
icosanoid biosynthetic process
cellular response to mechanical stimulus
positive regulation of release of cytochrome c from mitochondria
midgut development
response to toxic substance
lung development
animal organ development
system development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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