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Invitrogen
CD266 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-41232
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide containing amino acids 106-118 of human TweakR.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: human, mouse, or rat liver tissue or protein.
Immunogen sequence: CRREKFTTPI EETG
Target Information
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; fibroblast growth factor-regulated protein 2; tumor necrosis factor receptor superfamily, member 12a; tweak-receptor; type I transmembrane protein Fn14; unnamed protein product
Gene Aliases: CD266; FN14; HPIP; TWEAK-R; TWEAKR
UniProt ID: (Human) Q9NP84, (Mouse) Q9CR75
Entrez Gene ID: (Human) 51330, (Rat) 302965, (Mouse) 27279
positive regulation of apoptotic process
regulation of angiogenesis
regulation of wound healing
positive regulation of extrinsic apoptotic signaling pathway
substrate-dependent cell migration, cell attachment to substrate
cell adhesion
positive regulation of collagen biosynthetic process
positive regulation of axon extension
extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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