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Invitrogen
UBE2B Polyclonal Antibody
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Product Details
PA5-110674
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human UBE2B. Recombinant protein control fragment (Product #RP-105607).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LMRDFKRLQE DPPVGVSGAP SENNIMQWNA VIFGPEGTPF EDGTFKLVIE FSEEYPNKPP TVRFLSKMFH PNVYADGSIC LDILQNRWSP TYDVSSILTS IQSLLDEPNP NSPANSQAAQ
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2B is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2 protein; E2 ubiquitin-conjugating enzyme B; HHR6B (Human homologue of yeast RAD 6); putative; HR6B; RAD6 homolog B; UBE2B; Ubiquitin carrier protein B; ubiquitin conjugating enzyme E2B; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); Ubiquitin-protein ligase B; unnamed protein product
Gene Aliases: E2-17kDa; HHR6B; HR6B; RAD6B; UBC2; UBCH1; UBE2B
UniProt ID: (Human) P63146
Entrez Gene ID: (Human) 7320
protein polyubiquitination
in utero embryonic development
DNA repair
postreplication repair
chromatin organization
ubiquitin-dependent protein catabolic process
apoptotic process
cellular response to DNA damage stimulus
spermatogenesis
sperm axoneme assembly
response to xenobiotic stimulus
response to UV
positive regulation of reciprocal meiotic recombination
protein ubiquitination
ectopic germ cell programmed cell death
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
meiotic telomere clustering
protein stabilization
chiasma assembly
negative regulation of developmental process
protein autoubiquitination
synaptonemal complex organization
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
positive regulation of canonical Wnt signaling pathway
negative regulation of post-translational protein modification
negative regulation of reproductive process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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