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Invitrogen
Tankyrase 2 Polyclonal Antibody
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Product Details
PA5-111075
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Tankyrase 2. Recombinant protein control fragment (Product #RP-97049).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLDNLSGSFS ELSSVVSSSG TEGASSLEKK EVPGVDFSIT QFVRNLGLEH
Highest antigen sequence indentity to the following orthologs: Mouse - 78%, Rat - 80%.
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; Poly [ADP-ribose] polymerase tankyrase-2; poly(ADP-ribose) polymerase containing ankyrin repeats and SAM (sterile alpha module) motif; Protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; Tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein; telomerase binding protein; TNKL; tnks 2; TNKS-2; TNKS2; telomere-associated poly(ADP-ribose) polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; unnamed protein product
Gene Aliases: ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C; pART6; TANK2; TNKL; TNKS2
UniProt ID: (Human) Q9H2K2
Entrez Gene ID: (Human) 80351
NAD+ ADP-ribosyltransferase activity
protein binding
transferase activity
transferase activity, transferring glycosyl groups
nucleotidyltransferase activity
enzyme binding
metal ion binding
NAD+-protein-aspartate ADP-ribosyltransferase activity
NAD+-protein-glutamate ADP-ribosyltransferase activity
protein ADP-ribosylase activity
protein polyubiquitination
Wnt signaling pathway
positive regulation of telomere maintenance via telomerase
protein localization to chromosome, telomeric region
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
positive regulation of canonical Wnt signaling pathway
positive regulation of telomere capping
negative regulation of telomere maintenance via telomere lengthening
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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