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Invitrogen
SOCS3 Polyclonal Antibody
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Product Details
PA5-111637
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human SOCS3. Recombinant protein control fragment (Product #RP-105454).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FPSPPTEPSS EVPEQPSAQP LPGSPPRRAY YIYSGGEKIP LVLSRPLSSN VATLQHLCRK TVNGHLDSYE KVTQLPGPIR EFLDQYDAPL
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 93%.
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-3; Cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SOCS3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3; unnamed protein product
Gene Aliases: ATOD4; CIS3; Cish3; SOCS-3; SOCS3; SSI-3; SSI3
UniProt ID: (Human) O14543
Entrez Gene ID: (Human) 9021
signal transduction
JAK-STAT cascade
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
cell differentiation
intracellular signal transduction
negative regulation of apoptotic process
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
branching involved in labyrinthine layer morphogenesis
placenta blood vessel development
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
cellular response to interleukin-17
cellular response to leukemia inhibitory factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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