Search
Invitrogen
SIRT7 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-139782
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SIRT7. Recombinant protein control fragment (Product #RP-108766).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: LVVYTGAGIS TAASIPDYRG PNGVWTLLQK GRSVSAADLS EAEPTLTHMS ITRLHEQKLV QHVVSQNCDG LHLRSGLPRT AISE
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 95%.
Target Information
SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT7 is included in class IV. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; regulatory protein SIR2 homolog 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; SIR2-like protein 7; sir2-related protein type 7; sirtuin type 7; sirtuin7; unnamed protein product
Gene Aliases: SIR2L7
UniProt ID: (Human) Q9NRC8
Entrez Gene ID: (Human) 51547
chromatin binding
protein binding
protein methyltransferase activity
NAD-dependent protein deacetylase activity
protein-succinyllysine desuccinylase activity
protein-glutaryllysine deglutarylase activity
NAD+ binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
NAD-dependent protein-lysine depropionylase activity
NAD-dependent protein lysine deacylase activity
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
regulation of gluconeogenesis
regulation of DNA repair
regulation of transcription from RNA polymerase II promoter
protein deacetylation
cellular response to DNA damage stimulus
synapsis
rRNA transcription
negative regulation of transposition, RNA-mediated
regulation of mitochondrion organization
negative regulation of protein ubiquitination
regulation of gene expression, epigenetic
positive regulation of gluconeogenesis
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
positive regulation of transcription from RNA polymerase I promoter
regulation of protein export from nucleus
negative regulation of protein kinase B signaling
protein deglutarylation
R-loop processing
protein depropionylation
DNA repair-dependent chromatin remodeling
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of rRNA processing
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support