Invitrogen

MYOCD Polyclonal Antibody

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MYOCD Polyclonal Antibody

Product Details

PA5-139907

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MYOCD. Recombinant protein control fragment (Product #RP-109261).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2926909

Product Specific Information

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Immunogen sequence: ANQGIIPPLK RPAEFHEQRK HLDSDKAKNS LKRKARNRCN SADLVNMHIL QASTAERSIP TAQM

Highest antigen sequence indentity to the following orthologs: Rat - 75%, Mouse - 73%.

Target Information

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Myocardin

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Gene Aliases: MYCD; MYOCD

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UniProt ID: (Human) Q8IZQ8

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Entrez Gene ID: (Human) 93649

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Function(s)
core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding transcription factor binding histone acetyltransferase binding histone deacetylase binding R-SMAD binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of cell growth by extracellular stimulus vasculogenesis response to hypoxia cardiac ventricle development positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation transcription from RNA polymerase II promoter positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of cardiac muscle cell apoptotic process negative regulation of myotube differentiation positive regulation of transforming growth factor beta receptor signaling pathway cardiocyte differentiation regulation of histone acetylation hepatic stellate cell activation vascular smooth muscle cell differentiation positive regulation of DNA binding cellular component maintenance regulation of myoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction lung alveolus development digestive tract development positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation regulation of smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation uterus development urinary bladder development cell growth involved in cardiac muscle cell development cellular response to growth factor stimulus cellular response to hypoxia ductus arteriosus closure negative regulation of beta-amyloid clearance regulation of phenotypic switching positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation positive regulation of cardiac vascular smooth muscle cell differentiation positive regulation of cardiac muscle cell differentiation negative regulation of skeletal muscle cell differentiation
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