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Invitrogen
EHMT1 Polyclonal Antibody
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Product Details
PA5-139989
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EHMT1. Recombinant protein control fragment (Product #RP-109426).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: DCVVLFLSRD SDVTLKNKEG ETPLQCASLN SQVWSALQMS KALQDSAPDR PSPVERIVSR DIARGYERIP IPCVNAVDSE PCPSNYKYV
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 90%.
Target Information
EHMT1, also known as EUHMTASE1, is a histone methyltransferase. This protein methylates 'Lys-9' of histone H3 in vitro. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Eu-HMTase1; Euchromatic histone-lysine N-methyltransferase 1; G9a-like protein 1; GLP; H3-K9-HMTase 5; Histone H3-K9 methyltransferase 5; Histone-lysine N-methyltransferase EHMT1; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; Lysine N-methyltransferase 1D
Gene Aliases: bA188C12.1; EHMT1; Eu-HMTase1; EUHMTASE1; FP13812; GLP; GLP1; KIAA1876; KMT1D
UniProt ID: (Human) Q9H9B1
Entrez Gene ID: (Human) 79813
negative regulation of transcription from RNA polymerase II promoter
DNA methylation
embryo development
chromatin modification
histone methylation
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
negative regulation of transcription, DNA-templated
histone H3-K9 methylation
response to fungicide
histone H3-K27 methylation
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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