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Invitrogen
Granzyme K Polyclonal Antibody
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Product Details
PA5-144884
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 87-148. Recombinant protein control fragment (Product #RP-109096).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LSKNEASKQT LEIKKFIPFS RVTSDPQSND IMLVKLQTAA KLNKHVKMLH IRSKTSLRSG TK
Antigen sequence identity: Mouse 68%; Rat 66%
Target Information
Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fragmentin-3; granzyme 3; Granzyme K; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease, granzyme 3; tryptase II); Granzyme-3; GrK; NK-Tryp-2; NK-tryptase-2; tryptase II; unnamed protein product
Gene Aliases: GZMK; TRYP2
UniProt ID: (Human) P49863
Entrez Gene ID: (Human) 3003
activation of membrane attack complex
proteolysis
complement activation
opsonization
zymogen activation
killing of cells of other organism
positive regulation of inflammatory response
protein maturation
positive regulation of release of cytochrome c from mitochondria
granzyme-mediated programmed cell death signaling pathway
complement activation, GZMK pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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