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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: SCWKSENEKL LTQMESEKEN LQSKINHLET CLKTQQIKSH EYNERVRTLE MDRENLSVEI RNLHNVLDSK SVEVETQKLA YMELQQKAEF SDQKHQKEIE NMCLKTSQLT GQVEDLEHKL QLLSNEIMDK DRCYQDLHAE YE
Antigen sequence identity: Mouse 69%; Rat 73%
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitosis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AH antigen; CENP-F; Centromere protein F; Kinetochore protein CENPF; Mitosin; RP11-262H5.1
Gene Aliases: CENPF
Entrez Gene ID: (Human) 1063
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